Scientists in Japan and the United States have shown how the SARS-CoV-2 coronavirus breaks down the immune system 
CoV-2 can disrupt an important molecular pathway associated with an immune complex called the major immunocompatibility complex MHC-I. This could explain how the coronavirus escapes the body's defense systems. This was reported in an article published in the journal Nature Communications.
Scientists have demonstrated how the SARS-CoV-2 virus, which causes COVID-19, hacks gene expression in the immune system of patients. This allows the study of the function of complex cellular signaling pathways that trigger immune responses to fight bacteria and viruses. The MHC-I mechanism plays a central role in the immune response against viruses, allowing the infected cell to attract cytotoxic T cells.
The results showed that a protein from the SARS-CoV-2 virus called ORF 6, inhibits a host cell protein called NLRC5, which is responsible for MHC-I activation. ORF6 both interferes with cellular signaling, which disables NLRC5 expression, and directly blocks NLRC5 function. Further research will help find and test drugs that block the activity of the viral ORF6 protein.