Вход конем: почему «Омикрон» проникает в клетку лучше других штаммов

У нового варианта «Омикрон» есть три особые мутации, расположенные в узловом месте — в фуриновом сайте, который обеспечивает вход патогена в клетку. Это небывалое количество изменений в этом важном участке, и ими новый штамм принципиально отличается от других вариантов SARS-CoV-2, рассказали «Известиям» эксперты. Также «Омикрон» повторил многие опасные мутации «Альфы», «Беты», «Гаммы», «Дельты» и других вариантов. Впрочем, пока делать выводы о большей заразности нового штамма рано, отметили специалисты. Они призвали дождаться результатов более подробных исследований, которые будут готовы к концу года. Буду резать, буду бить Серьезных научных исследований по штамму «Омикрон» пока не проведено, так как он появился относительно недавно. Некоторые ученые считают, что этот вариант отделился от своего общего с другими ближайшими штаммами предка один-два месяца назад. Пока специалисты могут черпать информацию только из генома вируса, а результаты лабораторных тестов подоспеют через три-четыре недели. Однако уже сейчас ясно, что у нового варианта SARS-CoV-2 есть три особые мутации, расположенные в узловом месте. Им является фуриновый сайт, который нужен для того, чтобы обеспечить вирусу легкий вход в клетку. — Чтобы войти в клетку, вирус прикрепляется к ней своим шипом — бросает якорь, —

Created Cancer-Killing Cytokine Nanoparticles

Russian scientists have created a modified cytokine to suppress cancer Russian scientists have created polymer nanoparticles that kill cancer. These particles are associated with the anti-tumor protein TRAIL DR5, which causes cell death. The study is briefly described in a press release on the Godnauki.rf website. TRAIL is a cytokine that interacts with five cellular receptors. When binding to two of them – DR4 and DR5 – signals of apoptosis are triggered, that is, programmed cell death. However, the other three receptors inhibit signal transmission or block them altogether. In addition, the body itself may not produce enough cytokines to suppress tumor growth, and the artificially injected TRAIL is rapidly cleared from the body. Researchers have created modified cytokines that are more likely to bind to the DR4 or DR5 receptor. TRAIL DR5 targets DR5, and this modified cytokine is delivered to the target organ by nanoparticles consisting of amphiphilic

Created Cancer-Killing Cytokine Nanoparticles

Russian scientists have created a modified cytokine to suppress cancer Russian scientists have created polymer nanoparticles that kill cancer. These particles are associated with the anti-tumor protein TRAIL DR5, which causes cell death. The study is briefly described in a press release on the Godnauki.rf website. TRAIL is a cytokine that interacts with five cellular receptors. When binding to two of them – DR4 and DR5 – signals of apoptosis are triggered, that is, programmed cell death. However, the other three receptors inhibit signal transmission or block them altogether. In addition, the body itself may not produce enough cytokines to suppress tumor growth, and the artificially injected TRAIL is rapidly cleared from the body. Researchers have created modified cytokines that are more likely to bind to the DR4 or DR5 receptor. TRAIL DR5 targets DR5, and this modified cytokine is delivered to the target organ by nanoparticles consisting of amphiphilic

Russian senator named the reasons for the fall in Biden's rating

Senator Pushkov: Biden's rating is falling due to problems of domestic and foreign policy the reasons for the drop in the rating of US President Joe Biden. According to the senator, this is a natural phenomenon due to problems of domestic and foreign policy, including the imposition of tolerance and the ongoing coronavirus pandemic. ” A natural decline in Biden's rating: there is no action program, foreign policy is vague, bedlam in the country has been and remains, plus the epidemic is not waning. Here is the result, “Pushkov emphasized. Earlier it became known that most of the American voters blame US President Joe Biden, Congress, corporations and China for supply chain disruptions that have led to higher prices and a shortage of goods. Such data follows from a Morning Consult poll. Prior to this, the approval rating of Biden's policy among Americans reached a new anti-record and dropped to

The European Union urged to recognize Russian certificates of vaccination

MEP Ushakov called on the European Union to recognize Russian COVID certificates Former Mayor of Riga, MEP Ushakov from Latvia N vaccinated against COVID-19 by the Russian Sputnik V should be recognized in the European Union, and the certificates of those vaccinated by Pfizer or Moderna – in Russia, he wrote on Facebook. “The EU, Russia and China must mutually recognize vaccines. Certificates with “Sputnik” must work in the EU, and with the same Pfizer or Moderna – in Russia. We cannot allow a new closure of borders, “Ushakov urged. Earlier, the European Union told about the tests of the Sputnik V vaccine. The representative of the regulator Fergus Sweeney said that experts from the European Medicines Agency (EMA) continue to evaluate the Russian drug. Sweeney promised to inform when the experts move on to the next stage of research.

Onishchenko assessed the danger of the omicron strain

Honored Doctor of Russia Onishchenko urged not to panic because of the omicron-strain of coronavirus Onishchenko, in an interview with RIA Novosti, assessed the danger of the new omicron strain of coronavirus, saying that there is no reason for panic because of its appearance. health organizations, omicron is more infectious, but this happens with all new variants of the virus. According to the physician, now it is impossible to say that this is “something out of the ordinary, it is impossible.” “As for virulence, that is, the danger, while we, fortunately, do not see any new, more severe symptoms,” Onishchenko noted. Earlier, Professor and Head of the Department of Infectious Diseases at Cape Town Hospital Mark Mendelso called a way to combat the omicron strain of coronavirus. According to him, the main way to prevent the spread of the pandemic is vaccination. On November 11, a new strain of coronavirus

Onishchenko assessed the danger of the omicron strain

Honored Doctor of Russia Onishchenko urged not to panic because of the omicron-strain of coronavirus Onishchenko, in an interview with RIA Novosti, assessed the danger of the new omicron strain of coronavirus, saying that there is no reason for panic because of its appearance. health organizations, omicron is more infectious, but this happens with all new variants of the virus. According to the physician, now it is impossible to say that this is “something out of the ordinary, it is impossible.” “As for virulence, that is, the danger, while we, fortunately, do not see any new, more severe symptoms,” Onishchenko noted. Earlier, Professor and Head of the Department of Infectious Diseases at Cape Town Hospital Mark Mendelso called a way to combat the omicron strain of coronavirus. According to him, the main way to prevent the spread of the pandemic is vaccination. On November 11, a new strain of coronavirus

A soldier who tried to knock out the door with an ax bit a policeman

In the Odessa region, a man under the influence of drugs tried to knock out a colleague's door with an ax with an ax the door of someone else's apartment and bit the policeman who came to the call, UNIAN reports. The police received a message that an unknown person in military uniform is trying to cut through the door of one of the apartments with an ax. Law enforcement officers arrived at the scene and tried to detain the suspect, but he resisted and bit one of the policemen by the hand. Later it was possible to establish that a conflict occurred between the detainee and his colleague, who lived in the apartment into which he tried to break in. Eyewitnesses said that the incident took place in the village of Limanskoye. The man had an ax with him, as well as an object that looked like a knife.

A soldier who tried to knock out the door with an ax bit a policeman

In the Odessa region a man under the influence of drugs tried to knock out a colleague's door with an ax with an ax the door of someone else's apartment and bit the policeman who came to the call, UNIAN reports. The police received a message that an unknown person in military uniform is trying to cut through the door of one of the apartments with an ax. Law enforcement officers arrived at the scene and tried to detain the suspect, but he resisted and bit one of the policemen by the hand. Later it was possible to establish that a conflict occurred between the detainee and his colleague, who lived in the apartment into which he tried to break in. Eyewitnesses said that the incident took place in the village of Limanskoye. The man had an ax with him, as well as an object that looked like a knife.

The ex-head of the Russian colony was arrested on charges of taking bribes

The former head of IK-15 in Angarsk was arrested on charges of accepting a large bribe The former head of the correctional colony (IK-15) in Angarsk arrested on charges of accepting a large bribe of one million rubles. This was reported by RIA Novosti with reference to the Investigation Department of the Investigative Committee for the Irkutsk Region. According to the investigation, one of the subordinates gave a bribe to the defendant so that he would not be fired for gross violation of labor discipline. The criminal case was initiated on the basis of the materials of the Directorate of Internal Security of the Main Directorate of the Federal Penitentiary Service of Russia for the region. The ex-head of the colony was detained in Irkutsk, the court granted the petition for his detention for two months until January 24, 2022. This is the second case against the former head of