Disclosed is a method to eat and lose weight

Disclosed is a method to eat and lose weight

Biologists at Washington University in St. Louis (USA) found a way to prevent weight gain even while eating fatty foods. The researchers activated in the cells of mice of particular metabolic pathways. Article scientists published in the journal eLife, excerpts from it published in a press release on the website MedicalXpress.

Researchers have deduced genetically modified mice with overexpression (increased activity) of genes Hedgehog (Hh) — ΔNGli2 and SmoM2. These genes are involved in the development and maintenance of homeostasis of various tissues, including those formed by fat cells (adipocytes). The results of the experiments with the fruit fly Drosophila have shown that activation of Hh inhibits the growth and proliferation of adipocytes.

Animals were modified so that Hh genes could be activated when the mouse had stopped taking the antibiotic doxycycline (Dox), which the researchers added in the drinking water from birth rodents. Two months rodents for 16 weeks were fed with food with high content of fatty acids. At the same time one group of animals, referred to as Dox, the antibiotic was removed from the drinking water, and in the other (+Dox) continued to experience the effects of doxycycline.

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Through eight weeks of the experiment -Dox-mice body size and fat deposition was less than in rodents from the other group. Decreased levels of accumulation of as brown and white fat, decreased size of adipocytes. Results of molecular analysis showed that the activity of genes associated with growth and proliferation of adipocytes also decreased. Thus animals had increased insulin sensitivity, which is a factor preventing the development of diabetes.